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Langsjoen PH, Langsjoen PH, Folkers K. Long-term efficacy and safety of coenzyme Q10 therapy for idiopathic dilated cardiomyopathy. J Clin Pharmacol 1990;30:596-608. View abstract. View abstract. View abstract. The Huntington Study Group. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Am Heart J 2011;161(3):639-645. View abstract. Current Therapeutic Research 1990;47(5):841-845. View abstract. Biochem Biophys.Res Commun. Cordero, M. D., de, Miguel M., Moreno Fernandez, A. M., Carmona Lopez, I. M., Garrido, Maraver J., Cotan, D., Gomez, Izquierdo L., Bonal, P., Campa, F., Bullon, P., Navas, P., and Sanchez Alcazar, J. Arch Neurol. Arch Neurol 2007;64:938-44. View abstract. Br J Clin Pharmacol 1996;42:333-7. View abstract. View abstract. Golomb, B. View abstract. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Imanaka K, Izumiyama K, and Sakaguchi T et al. Nutrition 2012;28(3):250-255. J Support Oncol. Oda T. Effect of coenzyme Q10 on load-induced cardiac dysfunction: double blind study and investigation of dose-response relationship. 5-8-2003;341(3):201-204. A pilot clinical trial of the effects of coenzyme Q10 on chronic tinnitus aurium. Invest New Drugs 2001;19:81-3. Coenzyme Q10 does not improve simvastatin tolerability in dyslipidemic patients with prior statin-induced myalgia. View abstract. J Hypertens. Blood Purif. 2008;52(8):1345-1349. 2003;526:41-48. There is some evidence that taking coenzyme Q10 by mouth for at least one week before, A group of inherited disorders that cause muscle weakness and muscle loss (, A disease that causes curved, painful erections (. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials. View abstract. 1999;4(4):16-19. Effects of short-term supplementation with coenzyme Q10 on myocardial protection during cardiac operations. 2017;74(11):788-93.15. doi: 10.2146/ajhp160714. View abstract. Clin Exp Reprod Med. Current Therapeutic Research 1987;41(6):923-932. Ann.Intern.Med 11-7-2000;133(9):745-746. This survey is being conducted by the WebMD marketing sciences department. Agents may be broadly classified into four groups: • Alkylating agents damage the programs that control growth in the chromosomes of the tumour cells. View abstract. TikTokers are pretending to have horrible side-effects from COVID-19 vaccines. J Strength Cond.Res 2010;24(1):97-102. 1985;124(4):21S-28S. Isobe, C., Abe, T., and Terayama, Y. Early research suggests that taking an altered form of coenzyme Q10 called ubiquinol improves dry mouth. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. A. Coenzyme Q deficiency triggers mitochondria degradation by mitophagy. Klopstock, T., Yu-Wai-Man, P., Dimitriadis, K., Rouleau, J., Heck, S., Bailie, M., Atawan, A., Chattopadhyay, S., Schubert, M., Garip, A., Kernt, M., Petraki, D., Rummey, C., Leinonen, M., Metz, G., Griffiths, P. G., Meier, T., and Chinnery, P. F. A randomized placebo-controlled trial of idebenone in Leber's hereditary optic neuropathy. View abstract. View abstract. Biochemical and clinical aspects of Coenzyme Q10. View abstract. 2017 Mar;69(3):389-99. Oxid Med Cell Longev. Metabolic changes in patients with mitochondrial myopathies and effects of coenzyme Q10 therapy. 2006;79(6):1125-1129. View abstract. 2007;61(1):50-60. View abstract. Lipid-lowering drugs and mitochondrial function: Effects of HMG-CoA Reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Early research shows that taking coenzyme Q10 improve symptoms of depression in people over 55 years of age with bipolar disorder. Research shows that taking coenzyme Q10 does not slow the progression of ALS. 2009;85(10):647-651. 2019 Oct;148:104290. View abstract. Oral coenzyme Q10 supplementation improves clinical symptoms and recovers pathologic alterations in blood mononuclear cells in a fibromyalgia patient. Co-enzyme Q10: a new drug for cardiovascular disease. Research shows that taking coenzyme Q10 does not improve muscle strength, muscle function, or fatigue in polio survivors. View abstract. Suzuki S, Hinokio Y, Ohtomo M, et al. 2014;2014:798957. 1991;525-533. Sahebkar A, Simental-Mendía LE, Stefanutti C, Pirro M. Supplementation with coenzyme Q10 reduces plasma lipoprotein(a) concentrations but not other lipid indices: A systematic review and meta-analysis. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Barbiroli, B., Iotti, S., Cortelli, P., Martinelli, P., Lodi, R., Carelli, V., and Montagna, P. Low brain intracellular free magnesium in mitochondrial cytopathies. Mol.Aspects Med. Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. Mitochondrion. View abstract. 2017;17(1):433. doi: 10.1186/s12906-017-1933-7. JAMA 2003;289:1681-90. J Cardiovasc Pharmacol. Gan To Kagaku Ryoho 1982;9(1):116-121. Haginoya, K., Miyabayashi, S., Kikuchi, M., Kojima, A., Yamamoto, K., Omura, K., Uematsu, M., Hino-Fukuyo, N., Tanaka, S., and Tsuchiya, S. Efficacy of idebenone for respiratory failure in a patient with Leigh syndrome: a long-term follow-up study. Clin Investig 1993;71:S134-6. Zhou, M., Zhi, Q., Tang, Y., Yu, D., and Han, J. View abstract. View abstract. Singh, R. B., Wander, G. S., Rastogi, A., Shukla, P. K., Mittal, A., Sharma, J. P., Mehrotra, S. K., Kapoor, R., and Chopra, R. K. Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction. Coenzyme Q10 in the treatment of corneal edema in Kearns-Sayre: is there an application in Fuchs endothelial corneal dystrophy? Tell your doctor or pharmacist right away if you have any withdrawal symptoms such as restlessness, mental/mood changes (including anxiety, trouble sleeping, thoughts of suicide), watering eyes, runny nose, nausea, diarrhea, sweating, muscle aches, or sudden changes in behavior. Med J Aust. Nutrition Research 1997;17(6):941-945. Talk to your doctor about using methadone safely. View abstract. Lee, T. I., Kao, Y. H., Chen, Y. C., and Chen, Y. J. Proinflammatory cytokine and ligands modulate cardiac peroxisome proliferator-activated receptors. The effect of pravastatin and atorvastatin on coenzyme Q10. Drug Saf 2006;29:703-12. View abstract. Neurology 8-24-2004;63(4):727-729. View abstract. Welch KM. Mol.Aspects Med 1997;18 Suppl:S291-S298. A. Biofactors 2008;32(1-4):231-235. Oda T. Dose-effect relationship and critical dose of coenzyme Q10 on load-induced cardiac dysfunction in pediatric patients with mitral valve prolapse. A secondary analysis of a randomized clinical trial. View abstract. Soja AM, Mortensen SA. Buyse, G. M., Goemans, N., van den Hauwe, M., Thijs, D., de Groot, I. J., Schara, U., Ceulemans, B., Meier, T., and Mertens, L. Idebenone as a novel, therapeutic approach for Duchenne muscular dystrophy: results from a 12 month, double-blind, randomized placebo-controlled trial. November 10, 2013 at 3:00 p.m. UTC A growing branch of empirical health economics combines data and rigorous econometric method to tease … Approaches to therapy. Lister RE. J Neurol Sci 1998;156:41-6. Effect of coenzyme Q10 on myopathic symptoms in patients treated with statins. Res Commun.Mol Pathol.Pharmacol. Ugeskr Laeger 1998;160:3226-7. 2012;69(8):978-83. Watts GF, Castelluccio C, Rice-Evans C, et al. View abstract. View abstract. Heck AM, DeWitt BA, Lukes AL. Reduction of hypertension in patients by therapy with coenzyme Q10. Zh.Nevrol.Psikhiatr.Im S.S.Korsakova 2008;108(4):27-32. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension (review). Iwase S, Kawaguchi T, Yotsumoto D, et al. View abstract. View abstract. View abstract. If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Icon 10 Cs Solution medicine then it may not be safe to drive a vehicle or operate heavy machinery. Exp.Gerontol. In: Folkers K and Yamamura Y. Biomedical and Clinical Aspects of Coenzyme Q10. Plasma coenzyme Q(10) in children and adolescents undergoing doxorubicin therapy. Treatment of congestive heart failure with coenzyme Q10 illuminated by meta-analyses of clinical trials. View abstract. The effect of coenzyme Q10 on blood glucose and insulin requirement in patients with insulin dependent diabetes mellitus. In the case of a serious side effect, seek veterinary attention immediately. Highlights in Ubiquinone Research. No effect of combined coenzyme Q10 and selenium supplementation on atorvastatin-induced myopathy. Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension. Laaksonen, R., Fogelholm, M., Himberg, J. J., Laakso, J., and Salorinne, Y. Ubiquinone supplementation and exercise capacity in trained young and older men. View abstract. J Basic Clin Physiol Pharmacol. High blood pressure. Effects of coenzyme Q10 on statin-induced myopathy: a meta-analysis of randomized controlled trials. View abstract. Applying coenzyme Q10 to the gums is not effective for treating gum disease. View abstract. D'Andrea, G., Bussone, G., Allais, G., Aguggia, M., D'Onofrio, F., Maggio, M., Moschiano, F., Saracco, M. G., Terzi, M. G., Petretta, V., and Benedetto, C. Efficacy of Ginkgolide B in the prophylaxis of migraine with aura. Are you planning to see a doctor about switching your medication? Brain 2013;136(Pt 2):e230. Tiredness in people treated with cancer drugs. Antioxid.Redox.Signal. A systematic review and meta-analysis of randomized controlled trials. View abstract. Lancet 1995;346:1104-5. Wilkinson EG, Arnold RM, Folkers K, et al. Effect of coenzyme Q10 on essential hypertension: a double-blind controlled study. When this medication is used for a long time, it may not work as well. Neurosci.Lett. Heart Lung Circ 2010;19(10):584-591. View abstract. View abstract. Ann.Neurol. Chen, Y. F., Lin, Y. T., and Wu, S. C. Effectiveness of coenzyme Q10 on myocardial preservation during hypothermic cardioplegic arrest. This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. View abstract. Pandolfo, M. Introduction. What factors influenced or will influence your purchase? View abstract. Reduction of chemotoxicity and enhancement of antioxidant capacity of plasma in cancer patients treated with conventional therapy plus CoQ10. View abstract. In: Yamamura Y, Folkers K, Ito Y (eds). Digiesi V, Cantini F, Oradei A, et al. In: Folkers K, Littarru GP, and Yamagami T. Biomedical and clinical aspects of coenzyme Q. Amsterdam: Elsevier Science Publishers;1991. A case of diabetic amyotrophy associated with 3243 mitochondrial tRNA(leu; UUR) mutation and successful therapy with coenzyme Q10. Brain 2011;134(Pt 9):2677-2686. Ann.Neurol. View abstract. Talk to your doctor if you are using marijuana (cannabis). J Am Coll Nutr. Rengo F, Abete P, Landino P, et al. Symptoms of overdose may include: slow/shallow breathing, slow heartbeat, coma. View abstract. Endocr Pract 2003;9:417-70. Spigset O. View abstract. Clin Investig. 2006 Mar-Apr;12(2):26-31; quiz 32-3. During pregnancy, this medication should be used only when clearly needed. Oda, T. Recovery of the systolic time intervals by coenzyme Q10 in patients with a load-induced cardiac dysfunction. Feigin A, Kieburtz K, Como P, et al. Cyrus-Hajmassy, M. [Bilateral visual deterioration in excessive tobacco and alcohol consumption]. Other medications can affect the removal of methadone from your body, which may affect how methadone works. Lack of effect of coenzyme Q on left ventricular function in patients with congestive heart failure. View abstract. J Neurol Sci 1990;100:70-8. Clin Exp Rhuematol. Athletic performance. McGarry A, McDermott M, Kieburtz K, de Blieck EA, Beal F, Marder K,et al; Huntington Study Group 2CARE Investigators and Coordinators. Nutrition and heart failure: impact of drug therapies and management strategies. Higher quality studies are needed to confirm these results. Littarru, G. P., Nakamura, R., Ho, L., Folkers, K., and Kuzell, W. C. Deficiency of coenzyme Q 10 in gingival tissue from patients with periodontal disease. 1996;11(5):549-554. Balercia, G., Mancini, A., Paggi, F., Tiano, L., Pontecorvi, A., Boscaro, M., Lenzi, A., and Littarru, G. P. Coenzyme Q10 and male infertility. Store at room temperature away from light and moisture. Eiholzer, U., Meinhardt, U., Rousson, V., Petrovic, N., Schlumpf, M., and l'Allemand, D. Developmental profiles in young children with Prader-Labhart-Willi syndrome: effects of weight and therapy with growth hormone or coenzyme Q10. Isobe, C., Abe, T., and Terayama, Y. Celik, T. and Iyisoy, A. Coenzyme Q10 and coronary artery bypass surgery: what we have learned from clinical trials. Kernt, M., Hirneiss, C., Neubauer, A. S., Ulbig, M. W., and Kampik, A. Coenzyme Q10 prevents human lens epithelial cells from light-induced apoptotic cell death by reducing oxidative stress and stabilizing BAX / Bcl-2 ratio. View abstract. View abstract. Gazdikova, K., Gvozdjakova, A., Kucharska, J., Spustova, V., Braunova, Z., and Dzurik, R. [Effect of coenzyme Q10 in patients with kidney diseases]. Ishiyama, T., Morita, Y., Toyama, S., Yamagami, T., and Tsukamoto, N. A clinical study of the effect of coenzyme Q on congestive heart failure. Guastini, L., Mora, R., Dellepiane, M., Santomauro, V., Giorgio, M., and Salami, A. Water-soluble coenzyme Q10 formulation in presbycusis: long-term effects. Effect of ubidecarenone oral treatment on aerobic power in middle-aged trained subjects. Schneeberger, W., Muller-Steinwachs, J., Anda, L. P., Fuchs, W., Zilliken, F., Lyson, K., Muratsu, K., and Folkers, K. A clinical double-blind and crossover trial with coenzyme Q10 on patients with cardiac disease. View abstract. Neurology 8-23-2005;65(4):606-608. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. However, it doesn't seem to benefit people with normal coenzyme Q10 levels. Adjunctive treatment with coenzyme Q in periodontal therapy. See also Warning section. 2008;34(2):165-171. Do not double the dose to catch up. View abstract. Sunamori, M., Tanaka, H., Maruyama, T., Sultan, I., Sakamoto, T., and Suzuki, A. Bratisl.Lek.Listy 2010;111(4):205-211. Other side effects includes infection, headache, back pain, rash, asthenia, arthralgia, myalgia. II. Mori, T. A., Burke, V., Puddey, I., Irish, A., Cowpland, C. A., Beilin, L., Dogra, G., and Watts, G. F. The effects of [omega]3 fatty acids and coenzyme Q10 on blood pressure and heart rate in chronic kidney disease: a randomized controlled trial. Acta Neurol Scand 2019;139(3):284-93. doi: 10.1111/ane.13051. Some of these side effects may decrease after you have been using this medication for a while. View abstract. Roberts J. Folkers, K. and Wolaniuk, A. Decreasing the effectiveness of warfarin (Coumadin) might increase the risk of clotting. 2014;71(5):543-52. Morre, D. M., Morre, D. J., Rehmus, W., and Kern, D. Supplementation with CoQ10 lowers age-related (ar) NOX levels in healthy subjects. Mov Disord 1996;11:321-3. 2010;12(4):537-577. First Conference of the International Coenzyme Q10 Association 2002; Gvozdjakova A, Kucharska J, Lepies P, and et al. View abstract. In particular, the Labels may not reflect the actual information for individual states and countries. J Neurol. Phys.Sportsmed. Watts TLP. Assessment of coenzyme Q10 tolerability in Huntington's disease. Drug interactions may change how your medications work or increase your risk for serious side effects. Cancer. Res Commun.Chem.Pathol.Pharmacol 1976;14(4):721-727. B., Di Prospero, N. A., and Fischbeck, K. Clinical experience with high-dose idebenone in Friedreich ataxia. Rev.Neurol. Kidney damage in people with diabetes (diabetic nephropathy). SIDE EFFECTS Adverse events associated with the class of Sodium Iodide I-131 drug product include hypersensitivity reactions, radiation toxicities, and metabolic events. Murata, T., Ohtsuka, C., and Terayama, Y. 2008;48(4-6):191-201. Gold, R., Seibel, P., Reinelt, G., Schindler, R., Landwehr, P., Beck, A., and Reichmann, H. Phosphorus magnetic resonance spectroscopy in the evaluation of mitochondrial myopathies: results of a 6-month therapy study with coenzyme Q. Eur.Neurol. Am J Health Syst Pharm 2000;57:1221-7.